Acute cardiac care & resuscitation

Short-Term Outcomes of Heart Transplant Patients Bridged with Impella 5.5 Ventricular Assist Device

ESC Heart FailPublished Retrospective case series

Authors' conclusion

Impella 5.5 temporary left ventricular assist device optimizes care of heart transplant recipients providing superior haemodynamic support, mobility, improved renal function, pulmonary haemodynamics, and right ventricular function. Utilizing Impella 5.5 as a direct bridging strategy to heart transplantation resulted in excellent outcomes.

Study context

Population
Advanced HF patients bridged with Impella 5.5 to heart transplantation, March 2020–March 2021
Participants
16 patients
Outcome
Outcomes during Impella support and after transplantation

Main finding

As reported in the abstract

GroupValueLactate dehydrogenase, median (range)
Impella 5.5median 19 (range 3–31) days220 (149-430)

Impella 5.5

Valuemedian 19 (range 3–31) days
Lactate dehydrogenase, median (range)220 (149-430)
Median serum creatinine during Impella support decreased from 1.55 mg/dL to 1.25
P = 0.007
Pulmonary artery pulsatility index increased from 2.56 (0.86-10) to 4.2 (1.3-10)
P = 0.048
RV function improved
P = 0.003

Observational data: associations, not effects.

Original publication

Short-Term Outcomes of Heart Transplant Patients Bridged with Impella 5.5 Ventricular Assist Device. ESC Heart Fail. Published 3 May 2023. doi:10.1002/ehf2.14391

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