Short-Term PM2.5 Exposure and Cardiovascular Mortality: A Global Exposure-Response Analysis to Inform Alert Thresholds
Pooled result · CV mortality per 10 μg/m3 increase in short-term PM2.5Result — go to the resultPooled relative risk 1.0090 95% CI 1.0074–1.0106Authors' conclusion
A significant nonlinear relationship exists between short-term PM2.5 exposure and cardiovascular mortality.
Study context
- Population
- Epidemiologic studies of short-term PM2.5 exposure and CV mortality, global literature up to May 2025100 studies · 123 effect estimates
- Outcome
- Nonlinear exposure-response function for short-term PM2.5 exposure and CV mortality
Methodological details3-stage meta-regression model, global burden estimation
- 3-stage meta-regression model
- Global burden estimation
Pooled result
As reported in the abstract
CV mortality per 10 μg/m3 increase in short-term PM2.5
Pooled relative risk
1.0090
95% CI 1.0074–1.0106
Per 10 μg/m3 increase in short-term PM2.5
pooled RR 1.0090 (95% CI 1.0074–1.0106)
Per 10 μg/m3 increase in short-term PM2.5, as printed
Further pooled results
Global CV deaths attributable to PM2.5 pollution episodes (>75 μg/m3) · 2023
- Attributable CV deaths
- 59,399 (95% CI: 38,126-82,413)
Optimal alert value
- Optimal alert value
- 136 μg/m3 (95% CI: 129-148)
- Attributable deaths prevented
- 73.2% (95% CI: 71.8%-76.6%)
- At-risk person-days affected
- 32%
Original publication
Short-Term PM2.5 Exposure and Cardiovascular Mortality: A Global Exposure-Response Analysis to Inform Alert Thresholds. J Am Coll Cardiol. Published 18 February 2026. doi:10.
Summarised from the published abstract; every number is checked against it