Heart failure & cardiomyopathies
Significance of Common Genetic Variants Associated with Non-Ischaemic Cardiomyopathy in the General Population
Authors' conclusion
The NICM-GR correlates with LV function and dimension, and subsequent development of NICM in the general population.
Study context
- Population
- Unselected Olmsted County residents aged >45 years46 developed non-ischaemic cardiomyopathy (NICM)
- Participants
- 1,897 participants
- Exposure
- NICM genetic risk vs left ventricular (LV) function, dimensions and incident NICM
- Outcome
- Significance of common NICM-associated genetic variants (NICM-GR) in a general population
- Follow-up
- Median 16 years (IQR 15-17)
Methodological detailspopulation-based, matched cohort (3:1) for NICM development
- Population-based
- Matched cohort (3:1) for NICM development
Main finding
As reported in the abstract
NICM-GR vs LVEF, linear regression beta [SE]
−2.68
0.68p < 0.001
NICM-GR vs LV end-systolic diameter, beta [SE]
0.22
0.06p < 0.001
NICM-GR vs LV end-diastolic diameter, beta [SE]
0.14
0.06p = 0.01
NICM-GR and NICM development, OR
2.27 (1.06-4.85), p = 0.03 (95% CI)
Observational data: associations, not effects.
Further findings
HF biomarkers (aldosterone, natriuretic peptides, ST2, galectin-3)
- No significant association with NICM-GR
Age, sex and CV risk factors across NICM-GR quartiles
- No significant differences between quartiles
Original publication
Significance of Common Genetic Variants Associated with Non-Ischaemic Cardiomyopathy in the General Population. Eur J Heart Fail. Published 23 June 2025. doi:10.
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