Prevention & lipidsCohort study
Significance of lipids, lipoproteins, and apolipoproteins during the first 14–16 months of life
- Prospective cohort study
Authors' conclusion
Lipid parameters changed during the first 14-16 months of life, and sex, gestational age, birth weight, breastfeeding, and high parental concentrations influenced concentrations. Children with high concentrations of atherogenic lipid traits at birth had higher concentrations at 2 and 14-16 months.
Study context
- Population
- Children from birth to 14–16 months and their parents (Copenhagen Baby Heart Study)
- Participants
- 13,354 umbilical cord blood samples
- Outcome
- Lipid parameters (lipids, lipoproteins, apolipoproteins), influential factors, and whether high concentrations at birth predict high concentrations later
- Follow-up
- Birth, 2 months and 14-16 months
Main finding
As reported in the abstract
- Cord blood lipid concentrations correlated highly with newborn venous samples
- LDL-C, non-HDL-C, apolipoprotein B and lipoprotein(a) increased stepwise from birth to 2 months to 14-16 months
- LDL-C, non-HDL-C and lipoprotein(a) >80th percentile at birth associated with significantly higher concentrations at 2 and 14-16 months (linear mixed models)
- Lipid concentrations differed by sex, gestational age, birth weight, breastfeeding and parental lipid concentrations
- venous samples at birth (n = 444), 2 months (n = 364), 14-16 months (n = 168)
Observational data: associations, not effects.
Original publication
Significance of lipids, lipoproteins, and apolipoproteins during the first 14–16 months of life. Eur Heart J. Published 26 August 2023. doi:10.1093/eurheartj/ehad547
Summarised from the published abstract; every number is checked against it