Aortic & peripheral vascular disease
Simple Renal Cysts in Marfan Syndrome: Prevalence and Association With Aortic Events
Authors' conclusion
The prevalence of SRCs was significantly higher in patients with MFS compared to matched controls. SRCs were independently associated with aortic dissection in MFS. Prospective studies are needed to further evaluate whether SRCs could represent a marker of aortic disease severity in patients with MFS.
Study context
- Population
- Patients with marfan syndrome (MFS) ascertained by a pathogenic variant in the fibrillin-1 gene who underwent complete computed tomography scans, and matched controls131 patients with MFS and 131 controls, 2010–2016 · patients with MFS 131 · controls 131
- Participants
- 131 vs 131
- Comparison
- SRC prevalence in patients with MFS, compared to matched controls; association between simple renal cysts (SRCs) and aortic events in patients with MFS
- patients with MFSn = 131
- controlsn = 131
Main finding
As reported in the abstract
SRC prevalence
P < 0.0001
Further findings
SRC prevalence by aortic disease severity
- Patients with dissection
- 59%
- Patients with aortic aneurysm surgery
- 43%
- Patients with MFS but without aortic events
- 19%
- Controls
- 21%
- P < 0.009
Association of SRC presence with aortic dissection in patients with MFS (multivariable analysis)
- Adjusted OR
- 2.30 [95% CI: 1.00-5.32]; P = 0.049
- Independently associated
Baseline characteristics
- Mean age
- 40 ± 14 years
- Women
- 42%
Original publication
Simple Renal Cysts in Marfan Syndrome: Prevalence and Association With Aortic Events. JACC Adv. Published 17 June 2025. doi:10.
Summarised from the published abstract; every number is checked against it