Heart failure & cardiomyopathies
Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy
An erratum to this article was published (Circulation, 15 Apr 2025 ↗)
Authors' conclusion
Together, our study not only illustrated dynamically changing cell type crosstalk during pathological cardiac hypertrophy but also shed light on strategies for cell type- and stage-specific intervention in cardiac diseases.
Study context
- Population
- Mouse model of pressure overload-induced cardiac hypertrophy; human samples of hypertrophic cardiomyopathy and HF
- Participants
- 11,492 single cells
Methodological detailsmouse model, single-cell transcriptomics
- Mouse model
- Single-cell transcriptomics
Main finding
As reported in the abstract
- Dynamics of all major cardiac cell types (cardiomyocytes, endothelial cells, fibroblasts, macrophages) and subtypes during disease progression
- Stagewise utilization of specific noncardiomyocytes during deterioration of heart function
- Macrophage activation and subtype switching at middle-stage hypertrophy targeted by dapagliflozin (SGLT2 inhibitor), TD139 and Arglabin to preserve cardiac function and attenuate fibrosis
- Similar molecular patterns of hypertrophy in human hypertrophic cardiomyopathy and HF samples
Original publication
Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy. Circulation. Published 26 February 2020. doi:10.
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