Heart failure & cardiomyopathiesCohort study
Skeletal Muscle and Subcutaneous Fat Quantity as Prognostic Indicators in Cardiac Amyloidosis
- Retrospective cohort study
- consecutive patients
Authors' conclusion
Lower SMI was associated with increased mortality risk in patients with CA, particularly ATTR-CA.
Study context
- Population
- Patients with cardiac amyloidosis (ATTR or AL) diagnosed 2001–2021 with chest CT within 1 year before diagnosis
- Participants
- 160 patients
- Exposure
- CT body composition and mortality
- Outcome
- All-cause mortality
- Follow-up
- 10 years
Main finding
10-year mortality
HR per SD increase
0.69
95% CI 0.52–0.91
P = 0.010
SMI
HR per SD increase 0.69 (95% CI 0.52–0.91); P = 0.010
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mortality by sex-stratified tertiles · 1, 5 and 10 years
- Low vs high skeletal muscle index (SMI): 2 to 2.5 times higher 1-, 5- and 10-year mortality
- Medium vs high IMAT% and subcutaneous adipose tissue index (SATI): approximately 1.9 times higher 5- and 10-year mortality
By cardiac amyloidosis (CA) type (ATTR-CA vs AL-CA)
- Associations more pronounced in ATTR-CA; low SATI also predicted higher mortality
- AL-CA showed fewer significant associations
- Interaction by CA type not significant
Outcome-based SMI cutoffs for 10-year mortality
cm²/m²
- Males
- 23.5
- Females
- 27.8
- derived but need validation
Original publication
Skeletal Muscle and Subcutaneous Fat Quantity as Prognostic Indicators in Cardiac Amyloidosis. Eur J Heart Fail. Published 19 February 2025. doi:10.1002/ejhf.3622
Summarised from the published abstract; every number is checked against it