Cross-sectional study
Skeletal Muscle Mitochondrial Respiration and Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction
- Cross-sectional study
- age-matched controls
- single university referral centre
Data collected March 2016 to December 2017; analysed November 2020 to May 2021
Authors' conclusion
In this study, patients with HFpEF had marked abnormalities in skeletal muscle mitochondrial function.
Study context
- Population
- Clinically stable older adults (>60 years) with chronic heart failure with preserved ejection fraction (HFpEF) and age-matched healthy controls, not in regular exercise or diet programs
- Participants
- 72 adults
- Exposure
- HFpEF vs age-matched healthy controls
- Outcome
- Skeletal muscle mitochondrial function (maximal capacity, complex I- and complex II-linked respiration) and its association with exercise performance (peak VO2, 6-minute walk distance, SPPB)
Main finding
As reported in the abstract
Maximal capacity correlated with peak exercise oxygen consumption
R = 0.69; P < .001
Maximal capacity correlated with 6-minute walk distance
R = 0.70; P < .001
Maximal capacity correlated with Short Physical Performance Battery score
R = 0.46; P < .001
Observational data: associations, not effects.
Original publication
Skeletal Muscle Mitochondrial Respiration and Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. Published 1 June 2023. doi:10.1001/jamacardio.2023.0957
Summarised from the published abstract; every number is checked against it