Aortic & peripheral vascular disease
Sleep Pattern, Genetic Susceptibility, and Abdominal Aortic Aneurysm in UK Biobank Participants: Large-Scale Cohort Study
Authors' conclusion
In this large prospective study, healthy sleep patterns were associated with a lower risk of AAA among participants with low, intermediate, or high genetic risk.
Study context
- Population
- UK Biobank participants free of abdominal aortic aneurysm (AAA) at baseline1,622 incident AAA cases
- Participants
- 344,855 participants
- Exposure
- Sleep patterns and genetic risk vs healthy sleep pattern
- Outcome
- Incident AAA
- Follow-up
- Median 12.59 years
Methodological detailsCox proportional hazards regression
- Cox proportional hazards regression
Main finding
As reported in the abstract
Incident AAA · median 12.59 years
Hazard ratio (95% CI)
Per 1-point increase in sleep score
0.91(0.86–0.96)
Intermediate sleep pattern vs Healthy sleep pattern
1.18(1.06–1.31)
Poor sleep pattern vs Healthy sleep pattern
1.40(1.13–1.73)
Observational data: associations, not effects.
Further findings
AAA by joint sleep pattern and genetic risk (PRS tertiles, 22 SNPs)
- Poor sleep + high genetic risk vs healthy sleep + low genetic risk: 2.5-fold higher risk of AAA
Original publication
Sleep Pattern, Genetic Susceptibility, and Abdominal Aortic Aneurysm in UK Biobank Participants: Large-Scale Cohort Study. JACC Adv. Published 9 May 2024. doi:10.
Summarised from the published abstract; every number is checked against it