Prevention & lipidsCohort study
Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants
- Prospective cohort study
Authors' conclusion
In this large prospective study, a healthy sleep pattern was associated with reduced risks of CVD, CHD, and stroke among participants with low, intermediate, or high genetic risk.
Study context
- Population
- UK Biobank participants initially free of cardiovascular disease (CVD)
- Participants
- 385,292 participants
- Exposure
- Healthy sleep score 5 vs 0-1
- Outcome
- Incident CVD (CHD, stroke)
- Follow-up
- Median 8.5 years
Main finding
As reported in the abstract
Reduced risk, score 5 vs 0-1
CVD reduced risk
35% (19-48%)
Coronary heart disease (CHD) reduced risk
34% (22-44%)
Stroke reduced risk
34% (25-42%)
Observational data: associations, not effects.
Further findings
Incident events · median 8.5 years
- Incident CVD cases
- 7280
- CHD cases
- 4667
- Stroke cases
- 2650
CV events attributable to poor sleep pattern
- Nearly 10% of CV events attributable to poor sleep pattern
CHD and stroke by sleep pattern and genetic risk
- Poor sleep pattern and high genetic risk showed the highest risk of CHD and stroke
Original publication
Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants. Eur Heart J. Published 18 December 2019. doi:10.1093/eurheartj/ehz849
Summarised from the published abstract; every number is checked against it