Pulmonary vascular disease & thromboembolismCohort study
Sleep-Related Hypoxia, Right Ventricular Dysfunction, and Survival in Patients With Group 1 Pulmonary Arterial Hypertension
- Prospective cohort study
- multicentre cohort (PVDOMICS)
Authors' conclusion
Sleep-related hypoxia was more strongly associated than AHI with measures of RV dysfunction, death, or transplantation overall and in group 1 non-CTD-associated PAH but only with RV dysfunction in CTD-associated PAH.
Study context
- Population
- Patients with group 1 pulmonary arterial hypertension (PAH) with sleep studies, PVDOMICS cohort43 events
- Participants
- 186 patients
- Exposure
- Sleep-related hypoxia and apnea-hypopnea index (AHI), per 10-unit increment
- Outcome
- RV function measures and transplantation-free survival in association with AHI and T90 (per 10-unit increment)
Main finding
As reported in the abstract
Association with RV function and transplantation-free survival, per 10-unit increment
Change in RV ejection fraction (MRI), % (95% CI)P value
AHI
−2.18(−4.00 to −0.36)
P = 0.019T90
−0.93(−1.47 to −0.40)
P < 0.001Per 10-unit increment, as printed
Estimate (95% CI)P value
T90
change in RV systolic pressure(echocardiography) 2.52 mm Hg (1.61–3.43)
P < 0.001T90
change in mean pulmonary artery pressure(right heart catheterization) 0.27 mm Hg (0.05–0.49)
P = 0.019Per 10-unit increment, as printed
Hazard ratio (95% CI)
T905-year transplantation or death
1.17(1.07–1.28)
Per 10-unit increment, as printed
- T90
- Right ventricular (RV) hypertrophy (ECG) 1.24 mm (95% CI 1.10–1.40); P < 0.001
Observational data: associations, not effects.
Further findings
Transplantation or death, non-CTD-associated PAH (subgroup)
| Comparison | HR (95% CI) | |
|---|---|---|
| T90 | 1.21 (1.08–1.34) | |
| 0.512Hazard ratio (log scale) |
Connective tissue disease (CTD)-associated PAH (subgroup)
- T90 associated with RV dysfunction, but not death or transplantation
Original publication
Sleep-Related Hypoxia, Right Ventricular Dysfunction, and Survival in Patients With Group 1 Pulmonary Arterial Hypertension. J Am Coll Cardiol. Published 21 November 2023. doi:10.1016/j.jacc.2023.09.806
Summarised from the published abstract; every number is checked against it