Small Interfering RNA for LDL-Cholesterol Reduction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Pooled result · Mean percent change in LDL-C from baselineResult — go to the resultPooled mean LDL-C reduction −48.77% 95% CI −54.26 to −43.27Authors' conclusion
Inclisiran achieves substantial reductions in LDL-C across diverse patient populations. Its twice-yearly dosing schedule and small interfering RNA mechanism of action position inclisiran as a promising long-term lipid-lowering therapy, with potential for broader implementation as clinical experience and outcomes data continue to evolve. (Small Interfering RNA Therapy for LDL-Cholesterol Reduction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials; CRD420251178991.).
Study context
- Population
- Participants in randomized controlled trials comparing inclisiran with placebo, across diverse patient populations
- Participants
- 6,355 participants9 randomized control trials
- Comparison
- Inclisiran vs placebo in reducing low-density lipoprotein cholesterol (LDL-C) levels
- Outcome
- Mean percent change in LDL-C from baseline
Methodological detailsrandom-effects model using the generic inverse variance method
- Random-effects model using the generic inverse variance method
Pooled result
As reported in the abstract
Pooled mean LDL-C reduction
−48.77%
95% CI −54.26 to −43.27
P < 0.001
Inclisiranvs placebo
pooled mean LDL-C reduction −48.77% (95% CI −54.26 to −43.27); P < 0.001
Further pooled results
Follow-up duration
- Follow-up ranged from
- 0.5 to 1.5 years
Heterogeneity
- Significant heterogeneity
- I2 = 95%
- Largely attributable to differences in background lipid-lowering therapy and treatment intensification
Original publication
Small Interfering RNA for LDL-Cholesterol Reduction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. JACC Adv. Published July 2026. doi:10.
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