Cohort study
Small Left Ventricle in Patients With Atrial Fibrillation Is Associated With Increased Cardiovascular Risk
- Prospective cohort study
- registry-based
Authors' conclusion
In a prospective AF cohort, small LV was independently associated with an increased risk of cardiovascular events
Study context
- Population
- Patients with atrial fibrillation (AF) in the China-AF registry
- Participants
- 7,764 patients
- Exposure
- Small left ventricle (LV) and large LV vs normal LV size
- Small LVn = 308
- Large LVn = 429
- Outcome
- Composite CV events:
- CV death
- Ischemic stroke or systemic embolism
- Major bleeding
Main finding
As reported in the abstract
Composite CV events
Each group vs normal LVAdjusted hazard ratio (95% CI)
Small LV
1.54(1.07–2.20)
Large LV
1.36(1.02–1.81)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| CV death — Small LV vs Normal LV | 1.94 (1.14–3.28) | |
| CV death — Large LV vs Normal LV | 1.83 (1.24–2.69) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Left ventricular end-diastolic dimension (LVEDD) and composite CV events
- U-shaped relationship
- Pnonlinear < 0.001
Safety
| Outcome | aHR (95% CI) | |
|---|---|---|
| Major bleeding | 2.21 (1.01–4.86) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Small Left Ventricle in Patients With Atrial Fibrillation Is Associated With Increased Cardiovascular Risk. J Am Coll Cardiol. Published 21 May 2024. doi:10.1016/j.jacc.2024.03.394
Summarised from the published abstract; every number is checked against it