Coronary disease & ACSCohort study
Smoking and cardiovascular outcomes after percutaneous coronary intervention: a Korean study
- Retrospective cohort study
- nationwide database
Authors' conclusion
Smoking is associated with a higher risk of adverse outcomes in patients undergoing PCI. Quitters after PCI with <20 PYs were associated with a risk comparable with that of non-smokers.
Study context
- Population
- Patients undergoing Percutaneous Coronary Intervention (PCI), Korean National Health Insurance System, 2009–2016
- Participants
- 74,471 patients
- Exposure
- Current smokers and ex-smokers vs non-smokers after PCI
- Outcome
- MACCE:
- All-cause death
- MI
- Coronary revascularization
- Stroke
- Follow-up
- 4.0 years
Main finding
As reported in the abstract
MACCE · 4.0 years
Each group vs non-smokersAdjusted hazard ratio (95% CI)
Current smokers19.8% higher rate
1.198(1.137–1.263)
- Ex-smokers
- aHR 1.036 (95% CI .992-1.081)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| MACCE by smoking cessation and cumulative exposure (pre- and post-PCI check-up data) — Quitters 20-30 PYs vs Persistent non-smokers | 1.206 (1.054–1.380) | |
| MACCE by smoking cessation and cumulative exposure (pre- and post-PCI check-up data) — Quitters ≥30 PYs vs Persistent non-smokers | 1.227 (1.113–1.352) | |
| MACCE by smoking cessation and cumulative exposure (pre- and post-PCI check-up data) — Persistent smokers vs Persistent non-smokers | 1.223 (1.126–1.328) | |
| 0.512Adjusted hazard ratio (log scale) |
| Outcome | aHR (95% CI) |
|---|---|
| MACCE by smoking cessation and cumulative exposure (pre- and post-PCI check-up data) — Quitters <10 PY vs Persistent non-smokers | 1.182 (.971-1.438) |
| MACCE by smoking cessation and cumulative exposure (pre- and post-PCI check-up data) — Quitters 10-20 PYs vs Persistent non-smokers | 1.114 (.963-1.290) |
- Major adverse cardiovascular and cerebrovascular event (MACCE) by smoking cessation and cumulative exposure (pre- and post-PCI check-up data): n = 31 887 analysed
- MACCE by smoking cessation and cumulative exposure (pre- and post-PCI check-up data): P for interaction <.001
Original publication
Smoking and cardiovascular outcomes after percutaneous coronary intervention: a Korean study. Eur Heart J. Published 26 September 2023. doi:10.1093/eurheartj/ehad616
Summarised from the published abstract; every number is checked against it