Coronary disease & ACSCohort study
Smoking cessation after first ST-elevation myocardial infarction (STEMI) enhances infarct healing: a cardiac MRI study
- prospective study
Authors' conclusion
Smoking cessation after the first STEMI appears to be an important factor positively influencing infarct healing. Within the observation period, fewer patients died in the cessation group. In sum, these data provide another valuable argument for quitting smoking, even after an infarction had already occurred.
Study context
- Population
- Revascularized first-time STEMI patients382 (57%) active smokers at baseline
- Participants
- 672 patients
- Exposure
- Patients quitting smoking after STEMI vs continuing smokers
- cessation groupn = 183
Main finding
As reported in the abstract
- No differences in initial infarct size
Observational data: associations, not effects.
Further findings
Infarct size reduction · after 12 months · infarct size reduced more in the cessation group
P < 0.001
MACE (all-cause death and reinfarction) · median observation period of 3.4 years · MACE occurred less often in quitters
P = 0.005
Multivariable analyses
- Continuing smoking predictive of reduced infarct healing (multivariable logistic regression)
- Continuing smoking a marker for major adverse cardiac events (MACE), independent of traditional cardiovascular risk markers (multivariable Cox-regression)
Original publication
Summarised from the published abstract; every number is checked against it