Coronary disease & ACSMeta-analysis
Smoking Status at Baseline and 10-Year Outcomes After Drug-Eluting Stent Implantation
- Pooled individual participant data analysis of randomised trials
- multivariable-adjusted
Authors' conclusion
In patients undergoing PCI with DES, smoking at baseline is associated with an increased risk of death, MI, and ST, but a lower risk of repeat revascularization through to 10 years.
Study context
- Population
- Patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation with 10-year follow-up
- Participants
- 9,527 patients · 5 randomised trials
- Comparison
- Smoking vs nonsmoking at baseline
- Smokingn = 2,365
- Nonsmokingn = 7,162reference
- Outcome
- All-cause death
- Follow-up
- 10 years
Pooled result
As reported in the abstract
Adjusted hazard ratio
1.45
95% CI 1.33–1.59
Smoking vs Nonsmoking
HRadj 1.45 (95% CI 1.33–1.59)
Further pooled results
| Outcome | HRadj (95% CI) | |
|---|---|---|
| CV death · 10 years | 1.59 (1.41–1.80) | |
| Definite stent thrombosis · 10 years | 2.09 (1.34–3.26) | |
| MI · 1 to 10 years | 1.60 (1.36–1.90) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Myocardial infarction (MI) · 1 to 10 years
- MI risk comparable in the first 30 days after PCI
Repeat revascularization
- Lower risk of target lesion and target vessel revascularization with smoking
- Comparable risk of non-target vessel revascularization
Original publication
Smoking Status at Baseline and 10-Year Outcomes After Drug-Eluting Stent Implantation. JACC Cardiovasc Interv. Published 19 March 2025. doi:10.1016/j.jcin.2024.12.028
Summarised from the published abstract; every number is checked against it