Cohort study
Smoking trajectories and residual cardiovascular risk in patients with stable coronary artery disease: an international cohort study
- Prospective cohort study
- international registry
Authors' conclusion
Smoking reduction was not associated with improved CV outcomes. Most former smokers quit within a year of CAD diagnosis, and CV risk increase with each subsequent year of active smoking.
Study context
- Population
- Outpatients with stable coronary artery disease (CAD) (CLARIFY registry)
- Participants
- 32,378 outpatients
- Exposure
- Smoking cessation vs Never smokers
- Outcome
- Composite of:
- CV death
- MI
- Follow-up
- 5-year follow-up
Main finding
CV death and MI
Adjusted hazard ratio
0.56
95% CI 0.42–0.76
P < 0.001
Smoking cessation vs Never smokers
aHR 0.56 (95% CI 0.42–0.76); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Smoking cessation | Smoking quantity reduction | Former smokers | Never smokers |
|---|---|---|---|---|
| Smoking status at inclusion | Not reported in the abstract | Not reported in the abstract | 46.2% | Not reported in the abstract |
- Former smokers who quit within a year of CAD diagnosis
- 55.7%
- Smoking status at inclusion: Current smokers 12.5%
Original publication
Smoking trajectories and residual cardiovascular risk in patients with stable coronary artery disease: an international cohort study. Eur J Prev Cardiol. Published 19 April 2025. doi:10.1093/eurjpc/zwaf222
Summarised from the published abstract; every number is checked against it