Heart failure & cardiomyopathiesCohort study
Social Determinants of Health and Clinical Outcomes in Hypertrophic Cardiomyopathy
- Prospective cohort study
- multicenter
- 5 US sites (SHaRe registry)
Authors' conclusion
In this multicenter cohort study, residing in an area with lower median household income or worse SDI were each independently associated with adverse clinical outcomes in patients with HCM.
Study context
- Population
- US adults with hypertrophic cardiomyopathy (HCM) in the Sarcomeric Human Cardiomyopathy Registry, 2015–March 2024
- Participants
- 4,431 adults
- Exposure
- Lowest vs highest area-based median household income; highest vs lowest social deprivation index (SDI)
- Outcome
- Heart failure (HF), ventricular arrhythmias (VA) and overall composite (VA, HF, AF, stroke, death)
- Follow-up
- Median (IQR) 2.15 (0.15-5.82) years
Main finding
As reported in the abstract
HF, VA and overall composite outcome
Adjusted hazard ratio (95% CI)P value
Lowest income vs Highest incomeHF
2.07(1.77–2.42)
P < 0.001Lowest income vs Highest incomeVA
1.31(0.97–1.78)
P = 0.08Lowest income vs Highest incomeoverall composite
1.52(1.36–1.69)
P < 0.001Highest SDI vs Lowest SDIHF
1.48(1.29–1.70)
P < 0.001Highest SDI vs Lowest SDIVA
1.55(1.15–2.09)
P = 0.004Highest SDI vs Lowest SDIoverall composite
1.36(1.22–1.50)
P < 0.001Observational data: associations, not effects.
Original publication
Social Determinants of Health and Clinical Outcomes in Hypertrophic Cardiomyopathy. JAMA Cardiol. Published 1 February 2026. doi:10.1001/jamacardio.2025.4869
Summarised from the published abstract; every number is checked against it