Acute cardiac care & resuscitationRandomised controlled trial
Sodium Bicarbonate for In-Hospital Cardiac Arrest
- Randomised controlled trial
- parallel-group
- double-blind
- placebo-controlled
- 21 hospitals in Denmark
Authors' conclusion
There was no significant difference in sustained return of spontaneous circulation between sodium bicarbonate and placebo in adults with in-hospital cardiac arrest.
Study context
- Population
- Adults with in-hospital cardiac arrest who received at least 1 dose of epinephrine779 eligible for primary analyses
- Participants
- 913 adults
- Comparison
- Sodium bicarbonate vs placebo
- Sodium bicarbonaten = 372
- Placebon = 407reference
- Primary endpoint
- Sustained return of spontaneous circulation
Primary result
As reported in the abstract
Relative risk
1.05
95% CI 0.88–1.24
P = 0.62
Events by treatment group
Sodium bicarbonate vs Placebo
RR 1.05 (95% CI 0.88–1.24); P = 0.62
Secondary outcomes
| Outcome | Sodium bicarbonate | Placebo | RR (95% CI) | |
|---|---|---|---|---|
| Survival · 30 days | 12% | 9.1% | 1.25 (0.84–1.88) | |
| Favourable neurologic outcome (modified Rankin Scale 0–3) · 30 days | 8.1% | 5.4% | 1.39 (0.82–2.34) | |
| 0.512Relative risk (log scale) |
Safety
Alkalosis and hypernatremia after cardiac arrest
- More common with sodium bicarbonate
Original publication
Sodium Bicarbonate for In-Hospital Cardiac Arrest. JAMA. Published 25 August 2026. doi:10.1001/jama.2026.10628
Summarised from the published abstract; every number is checked against it