Coronary disease & ACSCohort study
Somatic and Germline Variants and Coronary Heart Disease in a Chinese Population
- Prospective cohort study
- 3 prospective cohorts
- targeted deep sequencing
Authors' conclusion
This study revealed that elevated CHD risk attributed to CHIP was nonnegligible even for small clones.
Study context
- Population
- Chinese adults without CVD or cancer at baseline, enrolled 2001 and 2008
- Participants
- 6,181 adults
- Exposure
- Clonal hematopoiesis of indeterminate potential (CHIP) carriers vs non-CHIP carriers
- CHIPn = 1,100
- Outcome
- First incident CHD
- Follow-up
- Median 12.17 years
Main finding
Incident CHD
Hazard ratio
1.42
95% CI 1.18–1.72
P = 2.82 × 10-4
CHIP vs Non-CHIP
HR 1.42 (95% CI 1.18–1.72); P = 2.82 × 10-4
As reported in the abstract
- Risk gradient with increasing VAF
- P = 3.98 × 10-3 for trend
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident CHD, small clones (VAF 0.5%-2%) (subgroup) | 1.33 (1.02–1.74) | P = 0.03 | |
| Incident CHD by PRS (subgroup) — CHIP, low PRS vs Non-CHIP | 1.02 (0.64–1.64) | P = 0.92 | |
| 0.512Hazard ratio (log scale) |
| Outcome | fold increase in risk (95% CI) | P value | |
|---|---|---|---|
| Incident CHD by PRS (subgroup) — CHIP, high PRS vs Non-CHIP, low PRS | 2.23 (1.51–3.29) | P = 6.29 × 10-5 | |
| −2024Difference (linear scale) |
- Incident coronary heart disease (CHD), small clones (VAF 0.5%-2%) (subgroup) — Median age, small clones vs VAF ≥2%
- 58.52 vs 62.70 years
Original publication
Somatic and Germline Variants and Coronary Heart Disease in a Chinese Population. JAMA Cardiol. Published 1 March 2024. doi:10.1001/jamacardio.2023.5095
Summarised from the published abstract; every number is checked against it