Pulmonary vascular disease & thromboembolism
SPARCL1 and N-terminal Pro-brain Natriuretic Protein (NT-proBNP) as Biomarkers of Right Ventricular-to-Pulmonary Artery Uncoupling in Pulmonary Hypertension
Authors' conclusion
SPARCL1 and NT-proBNP are good predictors of maladaptive RV remodelling and RV-PA uncoupling in IPAH patients. SPARCL1 may be a better predictor of early maladaptive RV remodelling than NT-proBNP.
Study context
- Population
- Patients with idiopathic pulmonary artery hypertension (IPAH) and controls without LV or right ventricular (RV) abnormalities, undergoing echocardiography and right heart catheterization with invasive RV pressure-volume (PV) loopsPatients with IPAH 73 · controls without LV or RV abnormalities 28
- Comparison
- SPARCL1 vs NT-proBNP for predicting maladaptive RV remodelling
- Outcome
- Association of SPARCL1 and NT-proBNP with load-independent RV function and RV-to-pulmonary artery (RV-PA) coupling (invasive PV loops); prediction of maladaptive RV remodelling
Performance
As reported in the abstract
Prediction of maladaptive RV remodelling (ROC)
| Test or model | AUC |
|---|---|
| SPARCL1 | 0.75 |
| NT-proBNP | 0.72 |
| SPARCL1 + NT-proBNP | 0.78 |
AUC
SPARCL10.75
NT-proBNP0.72
SPARCL1 + NT-proBNP0.78
- SPARCL1 vs NT-proBNP: P = 0.36
- SPARCL1 + NT-proBNP vs NT-proBNP: P = 0.16
- SPARCL1 + NT-proBNP vs SPARCL1: P = 0.18
Further findings
| Outcome | SPARCL1 | NT-proBNP | P value |
|---|---|---|---|
| RV EF < 50%SPARCL1 vs NT-proBNP | P = 0.06 | ||
| AUC | 0.77 | 0.67 | |
| RV end-diastolic diameter > 42 mmSPARCL1 vs NT-proBNP | P = 0.19 | ||
| AUC | 0.72 | 0.65 | |
| RVESVI > 31 mL/m²SPARCL1 vs NT-proBNP | PP = 0.10 | ||
| AUC | 0.78 | 0.71 |
SPARCL1 and NT-proBNP levels, IPAH vs controls
- Significantly higher in IPAH than controls
- P < 0.0001
SPARCL1 and NT-proBNP levels, maladaptive vs adaptive RV remodelling (IPAH)
- Higher with maladaptive RV remodelling
- P < 0.01
Original publication
SPARCL1 and NT-proBNP as Biomarkers of Right Ventricular-to-Pulmonary Artery Uncoupling in Pulmonary Hypertension. ESC Heart Fail. Published 9 December 2024. doi:10.
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