Acute cardiac care & resuscitationCohort study
Spectral Characteristics and Parameters of Pulse Oximetry Waveforms for Assessing Resuscitation Status
- multicentre retrospective study
Authors' conclusion
Pulse oximetry plethysmography waveform analysis-using signals already available on standard monitors-may provide a non-invasive, real-time approach that may help identify ROSC during ongoing compressions and distinguish between stable and unstable circulation.
Study context
- Population
- Adult patients with cardiac arrest from 14 Chinese tertiary hospitals (2013–2018)OHCA episodes 158 · In-Hospital Cardiac Arrest (IHCA) episodes occurring in the ED 339
- Participants
- 451 patients · 497 cardiopulmonary resuscitation (CPR) episodes
- Exposure
- Time-domain (POPAUC) and frequency-domain spectral features of pulse oximetry plethysmography (POP) waveforms evaluated against clinically documented ROSC
Main finding
As reported in the abstract
Frequency-domain "hybrid" pattern during CC+ROSC identifying ROSC
specificity
100%
PPV
1.000
Observational data: associations, not effects.
Further findings
| Outcome | CC | CC+ROSC | non-compression without ROSC | SC | P value |
|---|---|---|---|---|---|
| POPAUC in CC status, stable-ROSC vs unstable-ROSC · higher in stable-ROSC | P = 0.007 | ||||
| POPAUC, CC+ROSC vs SC status, stable-ROSC · lower in CC+ROSC | Not reported in the abstract | 2768.2 ± 997.8 PVPG | Not reported in the abstract | 3335.8 ± 842.4 PVPG | P = 0.001 |
| POPAUC, CC+ROSC vs SC status, unstable-ROSC · reverse observed (higher in CC+ROSC) | Not reported in the abstract | 2697.5 ± 941.0 PVPG | Not reported in the abstract | 1338.1 ± 952.6 PVPG | P < 0.001 |
- POPAUC in CC status, stable-ROSC vs unstable-ROSC: stable-ROSC 3232.2 ± 1008.2 PVPG
- POPAUC in CC status, stable-ROSC vs unstable-ROSC: unstable-ROSC 2769.6 ± 1013.0 PVPG
POP waveform disappearance with concurrent ECG presence identifying pulseless electrical activity
- specificity
- 100%
Original publication
Spectral Characteristics and Parameters of Pulse Oximetry Waveforms for Assessing Resuscitation Status. Resuscitation. Published 7 October 2026. doi:10.1016/j.resuscitation.2026.111346
Summarised from the published abstract; every number is checked against it