Arrhythmias & electrophysiology
Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2
Authors' conclusion
Spexin reduces atrial fibrillation susceptibility by inhibiting CREB phosphorylation and thus downregulating KCNJ2 and SLN transcription by GALR2 receptor.
Study context
- Population
- Patients with and without atrial fibrillation (AF); Spexin knockout (SPX-KO), GALR-cKO and Ang-II-infused mice
Main finding
As reported in the abstract
- Lower plasma spexin in patients with AF than in subjects without AF
- Spexin knockout increased AF susceptibility in mice
- SPX-KO atrium: KCNJ2 and sarcolipin (SLN) upregulated; IK1 current increased and Ca2+ handling impaired in atrial myocytes
- GALR2-cKO, but not GALR1-cKO or GALR3-cKO, mice had higher AF incidence, with higher IK1 current and intracellular Ca2+ overload
- CREB phosphorylation upregulated in atria of SPX-KO and GALR2-cKO mice; p-CREB recruited to KCNJ2 and SLN proximal promoters
- Spexin treatment suppressed CREB signalling, decreased IK1 and intracellular Ca2+ overload, and reduced AF inducibility in Ang-II-infused mice
Original publication
Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2. Circulation. Published 10 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →