Heart failure & cardiomyopathiesCohort study
Spinal Stenosis and Carpal Tunnel Syndrome as Surrogates of Transthyretin Amyloid Cardiomyopathy
- Retrospective population-based cohort study
- age- and sex-matched controls (3 per case)
Authors' conclusion
LSS and CTS were associated with increased likelihood of cardiovascular events and amyloidosis diagnosis. This highlight the importance of a dedicated assessment of cardiovascular symptoms for LSS/CTS patients, particularly if both conditions are present.
Study context
- Population
- Patients aged 50–90 years with lumbar spinal stenosis (LSS)/carpal tunnel syndrome (CTS) diagnosis between 1995 and 2015, identified through Rochester Epidemiology Project (Minnesota, USA)LSS and CTS cohorts with matched controls · LSS cases 6,076 · LSS controls 16,205 · CTS cases 6,664 · CTS controls 17,462
- Participants
- 6,076 / 16,205 / 6,664 / 17,462
- Exposure
- LSS and CTS cases vs age- and sex-matched controls
- LSS casesn = 6,076
- LSS controlsn = 16,205reference
- CTS casesn = 6,664
- CTS controlsn = 17,462reference
Main finding
As reported in the abstract
Baseline comorbidities and cardiac events
- LSS and CTS cases had more comorbidities at baseline and higher likelihood of cardiac events compared to controls
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Survival — LSS cases vs LSS controls · worse survival in LSS cases | 1.26 (1.19–1.33) | P < 0.001 | |
| Survival — CTS cases vs CTS controls · similar survival | 0.95 (0.90–1.01) | P = 0.10 | |
| 0.512Hazard ratio (log scale) |
Amyloidosis diagnosis · 10-year — LSS cases vs LSS controls
cause-specific HR 2.18 · P < 0.001
| Outcome | cause-specific HR | P value |
|---|---|---|
| Amyloidosis diagnosis · 10-year — CTS cases vs CTS controls | 2.87 | P < 0.001 |
Amyloidosis incidence in patients with both LSS and CTS · 10-year
- 10-year incidence rate of amyloidosis, patients with both LSS and CTS
- 1.45%
Original publication
Spinal Stenosis and Carpal Tunnel Syndrome as Surrogates of Transthyretin Amyloid Cardiomyopathy. JACC Adv. Published 20 January 2026. doi:10.1016/j.jacadv.2025.102545
Summarised from the published abstract; every number is checked against it