Coronary disease & ACSCohort study
Spontaneous Coronary Artery Dissection in Highly Active Individuals
- prospective spontaneous coronary artery dissection (SCAD) registry
- Mayo Clinic SCAD "Virtual" Multi-Center Registry
- supplemental survey
Authors' conclusion
HAIs with SCAD demonstrate a distinct clinical profile which may represent a unique phenotype. HAIs with SCAD were not at higher risk of recurrence or major adverse cardiac event at 10-year follow-up.
Study context
- Population
- Participants with angiographically confirmed SCADcompleted vital components of a supplemental survey · highly active individuals (HAIs) 245 · non-HAIs 588
- Participants
- 833 participants
- Exposure
- Characteristics and outcomes were compared between HAIs and non-HAIs
- HAIsn = 245
- non-HAIsn = 588
Main finding
As reported in the abstract
Hypertension, smoking, body mass index
- HAIs had a lower prevalence of hypertension, smoking, and lower body mass index
Observational data: associations, not effects.
Further findings
Exercise-related SCAD · much more common in HAIs
P < 0.001
Out-of-hospital cardiac arrest in association with exercise
P = 0.012
SCAD presentation · initial SCAD event
- HAIs more likely to present with non-ST-segment elevation myocardial infarction and cardiac arrest
- HAIs less likely with ST-segment elevation myocardial infarction, multivessel or left main SCAD, or pregnancy-associated SCAD
Recurrent SCAD and major adverse cardiac events
- did not differ between groups
Original publication
Spontaneous Coronary Artery Dissection in Highly Active Individuals. JACC Adv. Published 2 January 2026. doi:10.1016/j.jacadv.2025.102485
Summarised from the published abstract; every number is checked against it