Valvular & structural heart diseaseCohort study
Staging Extramitral Cardiac Damage in Mitral Annular Calcification With Mitral Valve Dysfunction
- Retrospective cohort study
- single-centre
Authors' conclusion
Using the proposed extramitral cardiac damage staging system in patients with MAC and significant mitral valve dysfunction, more advanced stages are associated with higher mortality.
Study context
- Population
- Adults with mitral annular calcification (MAC) and significant mitral valve dysfunction (mitral stenosis and/or at least moderate mitral regurgitation) undergoing TTE over 1 year at Mayo Clinic
- Participants
- 953 adults
- Exposure
- Extramitral cardiac damage stages 2, 3 and 4 vs stages 0 to 1
- Stages 0 to 1n = 28reference
- Stage 2n = 499
- Stage 3n = 115
- Stage 4n = 311
- Outcome
- All-cause mortality and HF hospitalization
- Follow-up
- 3.8-year follow-up
Main finding
As reported in the abstract
All-cause mortality
- Mortality significantly higher in stages 2 to 4 vs stages 0 to 1 and increased with each stage
- Survival differences maintained after adjustment for age, DM and glomerular filtration rate
Observational data: associations, not effects.
Further findings
HF hospitalization
- Significantly higher in stages 3 and 4 vs stages 0 to 1
Subgroups: moderate or severe MAC, predominant mitral stenosis, predominant mitral regurgitation
- Similar results observed
Original publication
Staging Extramitral Cardiac Damage in Mitral Annular Calcification With Mitral Valve Dysfunction. JACC Cardiovasc Interv. Published 8 July 2024. doi:10.1016/j.jcin.2024.05.031
Summarised from the published abstract; every number is checked against it