Prevention & lipidsCohort study
Statin use for primary prevention of cardiovascular disease among apparently healthy adults
- Nationwide cohort study
- registry-based
Authors' conclusion
High statin adherence among apparently healthy users was associated with a significant risk reduction of major cardiovascular adverse events.
Study context
- Population
- Apparently healthy adults aged 40–85 years using statins for primary prevention (no CVD, DM, COPD, hepatic disease, cancer or parental CVD), Denmark, 1997–2022
- Participants
- 151,791 adults
- Exposure
- Moderate or high vs low statin adherence
- Outcome
- Composite of:
- MI
- Stroke
- CV death
- Follow-up
- 5 years
Main finding
As reported in the abstract
5-year major CV risk
Each group vs lowHazard ratio (95% CI)
Moderate
0.87(0.75–1.01)
High
0.66(0.58–0.75)
Observational data: associations, not effects.
Original publication
Statin use for primary prevention of cardiovascular disease among apparently healthy adults. Eur J Prev Cardiol. Published 24 June 2025. doi:10.1093/eurjpc/zwaf357
Summarised from the published abstract; every number is checked against it