Prevention & lipidsCohort study
Statins and survival free of incident frailty among older US veterans
- Retrospective cohort study
- propensity-score weighted (overlap)
Authors' conclusion
Statin initiation was associated with a significantly lower risk of incident frailty or death among older US veterans including those who were pre-frail at baseline.
Study context
- Population
- Statin-naïve, non-frail US veterans aged ≥67 years in regular Veteran Affairs (VA) care, 2002–2018
- Participants
- 987,301 participants
- Exposure
- Statin initiation vs no statin initiation
- Statin initiatorsn = 290,729
- Outcome
- Composite of incident frailty with censoring at death
- Follow-up
- Mean 5.3 (SD 4.1) years
Main finding
As reported in the abstract
Hazard ratio
0.76
95% CI 0.75–0.76
By group
Statin initiators vs Non-initiators
HR 0.76 (95% CI 0.75–0.76)
Observational data: associations, not effects.
Further findings
Incident frailty in pre-frail veterans (VA-Frailty Index (VA-FI) 0.1-0.2)
- Similar results in pre-frail veterans
Original publication
Statins and survival free of incident frailty among older US veterans. Eur Heart J. Published 10 June 2026. doi:10.1093/eurheartj/ehag451
Summarised from the published abstract; every number is checked against it