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Coronary disease & ACSRandomised controlled trial

Stellate Ganglion Block Reduces the Incidence of Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting

JACC Clin ElectrophysiolPublished

  • randomized
  • modified intention-to-treat
  • per-protocol analysis
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Authors' conclusion

In patients undergoing coronary artery bypass grafting with cardiopulmonary bypass, preemptive left SGB was associated with a reduced incidence of POAF within 5 postoperative days. Exploratory subgroup analyses suggested a potentially greater association among patients without diabetes and those at lower risk of POAF.

Study context

Population
Patients undergoing coronary artery bypass grafting with cardiopulmonary bypassunderwent initial randomization, 108 in modified intention-to-treat and 98 in per-protocol analysis · modified intention-to-treat 108 · per-protocol 98
Participants
124 patients
Comparison
Stellate ganglion block (SGB) group vs control group
Primary endpoint
Incidence of POAF
Follow-up
Within 5 days postoperatively

Primary result

As reported in the abstract

Odds ratio

0.288

95% CI 0.106–0.731

P = 0.007

By group

SGB group vs control group
OR 0.288 (95% CI 0.106–0.731); P = 0.007

Secondary outcomes

OutcomeOR (95% CI)P value
POAF incidence, exploratory subgroups — SGB group vs control group · patients without diabetes · Exploratory subgroup analyses0.10 (0.019–0.480)P = 0.004
POAF incidence, exploratory subgroups — SGB group vs control group · lower baseline risk of POAF · Exploratory subgroup analyses0.10 (0.005–0.642)P = 0.040

Postoperative atrial fibrillation (POAF) burden, duration of first POAF episode, POAF episodes, antiarrhythmic treatments, C-reactive protein, interleukin-6, high-sensitivity cardiac troponin T, creatine kinase-MB, postoperative hospitalization · certain postoperative time points

SGB group showed significantly lower POAF burden, shorter duration of first POAF episode, fewer POAF episodes and antiarrhythmic treatments, decreased C-reactive protein, interleukin-6, high-sensitivity cardiac troponin T, and creatine kinase-MB, and decreased postoperative hospitalization than the control group
all P < 0.05

Original publication

Stellate Ganglion Block Reduces the Incidence of Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting. JACC Clin Electrophysiol. Published 21 September 2026. doi:10.1016/j.jacep.2026.07.006
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Summarised from the published abstract; every number is checked against it