Coronary disease & ACSRandomised controlled trial
Stent Retriever Thrombectomy in Patients With Myocardial Infarction
- Randomised controlled trial
- open-label
- multicentre
- superiority
Authors' conclusion
Stent-retriever thrombectomy followed by conventional PCI in patients with large thrombus burden undergoing primary PCI ≤8 hours of symptom onset was associated with reduced infarct size vs conventional PCI alone.
Study context
- Population
- STEMI with large thrombus burden at angiography (TIMI thrombus grade ≥3 in infarct-related artery)randomised
- Participants
- 156 participants
- Comparison
- Stent-retriever vs Conventional
- Stent-retrievern = 78
- Conventionaln = 76reference
- Primary endpoint
- Infarct size by creatine kinase-MB AUC
Primary result
Infarct size (CK-MB AUC)
Difference
−1,359
95% CI −2,231 to −522
P = 0.001
By group
As reported in the abstract
Further findings
| Outcome | Stent-retriever | Conventional | difference (95% CI) | |
|---|---|---|---|---|
| Infarct size by CMR (% LV), exploratory · exploratory | 17% (IQR 11%–28%) · n = 64 | 28.0% (IQR 18%–33%) · n = 59 | −7.0 (−12 to −2.0) | |
| −15−10−505Difference (linear scale) |
Infarct size by CMR (% LV), exploratory
- LV volumes and EF did not differ
Safety
| Outcome | Stent-retriever | Conventional |
|---|---|---|
| MACE (CV death, nonfatal MI, nonfatal stroke) · 3 and 30 days | ||
| 3 days | 0 | 2 |
| 30 days | 1 | 3 |
Original publication
Stent Retriever Thrombectomy in Patients With Myocardial Infarction. J Am Coll Cardiol. Published 29 August 2026. doi:10.1016/j.jacc.2026.08.034
Summarised from the published abstract; every number is checked against it