Valvular & structural heart diseaseTrial design
STrategies for antithrombotic tRreatment following transcatheter edge-to-edge repair in patients with severe mitral regurgitation: Rationale and design of STAR-TEER trial
- investigator-initiated, multicenter, randomized, parallel controlled, open-label trial
- rationale and design
- hierarchical hypothesis testing
Study context
- Population
- Post-TEER patients with severe mitral regurgitation, with or without indications for oral anticoagulation (OAC)planned enrollment, stratified into 2 cohorts · Cohort A (requiring long-term OAC) 880 · Cohort B (no OAC indication) 1,032
- Participants
- 1,912 patients
- Planned comparison
- de-escalated antithrombotic strategies with monotherapy in post-TEER patients with or without indications for oral anticoagulation (OAC)
- Primary endpoint
- all bleeding complications
- Follow-up
- Within 12 months post-TEER
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
STrategies for antithrombotic tRreatment following transcatheter edge-to-edge repair in patients with severe mitral regurgitation: Rationale and design of STAR-TEER trial. Am Heart J. Published 28 January 2026. doi:10.1016/j.ahj.2026.107362
Summarised from the published abstract; every number is checked against it