Coronary disease & ACSRandomised controlled trial
Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial
- Randomised controlled trial
- multicentre
- terminated early
- Terminated early upon Data and Safety Monitoring Board recommendation due to clear benefit in the intervention group and potential harm in the control group
Authors' conclusion
In this first randomized trial of treatment strategies in MINOCA, a stratified treatment, based on comprehensive diagnostic assessment and aetiology-guided therapy, led to a significant improvement in angina-related health status.
Study context
- Population
- Patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) (myocardial infarction with non-obstructive coronary arteries)92 analysed
- Participants
- 101 patients
- Comparison
- Stratified treatment vs standard care
- Stratified treatmentn = 45
- Standard caren = 47reference
- Primary endpoint
- Between-group difference in change in angina status by Seattle Angina Questionnaire summary score (SAQSS)
- Follow-up
- 12 months
Primary result
SAQSS
Mean between-group difference
+9.38
95% CI 6.81–11.95
P < 0.001
As reported in the abstract
Secondary outcomes
MACE (all-cause mortality, MI, stroke, HF hospitalization, repeated coronary angiography) · not statistically significant
P = 0.18
Original publication
Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial. Eur Heart J. Published 28 October 2025. doi:10.1093/eurheartj/ehaf917
Summarised from the published abstract; every number is checked against it