Arrhythmias & electrophysiologyCohort study
Strength-Based Exercise Is Not Associated With Ventricular Arrhythmia in Arrhythmogenic Cardiomyopathy—Towards Safer Exercise Options
- Johns Hopkins ARVC Registry
Authors' conclusion
Our study found no association between strength exercise and risk of sustained VA. These findings support individualized risk stratification and shared decision-making in ACM care and show the need for additional studies to guide recommendations.
Study context
- Population
- Individuals with arrhythmogenic cardiomyopathy (ACM) and/or P/LP ACM gene variants exposed to strength-based exerciseindividuals enrolled, median age 34 years
- Participants
- 355 individuals
- Exposure
- endurance vs strength exercise on ventricular arrhythmia (VA) risk
Main finding
As reported in the abstract
Distribution of exercise groups
Observational data: associations, not effects.
Further findings
Overall lifetime risk of VA
- Higher with increased aerobic exercise (dual + endurance) than without (strength + sedentary)
- No difference between dual vs endurance athletes, nor strength athletes vs sedentary
VA (multivariable Cox regression)
- No association of VA with strength training, whereas risk of endurance exercise was significant
- multivariable
Original publication
Strength-Based Exercise Is Not Associated With Ventricular Arrhythmia in Arrhythmogenic Cardiomyopathy—Towards Safer Exercise Options. JACC Clin Electrophysiol. Published 29 August 2026. doi:10.1016/j.jacep.2026.07.035
Summarised from the published abstract; every number is checked against it