Coronary disease & ACSCross-sectional study
Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort
- Cross-sectional study
- population-based
Authors' conclusion
This study provides evidence of an association of a gut microbiota composition characterized by increased abundance of Streptococcus spp and other species commonly found in the oral cavity with coronary atherosclerosis and systemic inflammation markers.
Study context
- Population
- Adults aged 50 to 65 years without overt atherosclerotic disease, population-based SCAPIS cohort
- Participants
- 8,973 adults
- Outcome
- Associations of gut microbiota species abundance (shotgun metagenomics) with CAC score and coronary CT angiography measures, adjusted for CV risk factors
Main finding
As reported in the abstract
Species associated with CAC score independent of CV risk factors
64
Strongest associations: Streptococcus anginosus and Streptococcus oralis subsp oralis
P<1×10-5
Observational data: associations, not effects.
Further findings
Coronary atherosclerosis prevalence
- Coronary artery calcification detected
- 40.3%
- At least 1 stenosis with >50% occlusion
- 5.4%
Inflammatory markers
- Of the 64 species, associated with hs-CRP plasma concentrations
- 19
- Of the 64 species, associated with neutrophil counts
- 16
Plasma metabolites
- Oral-cavity gut species negatively associated with plasma indole propionate and positively with plasma secondary bile acids and imidazole propionate
Saliva and dental health
- Species, including 3 streptococci, correlated with the same species in saliva and associated with worse dental health (Malmö Offspring Dental Study)
- 5
Microbial functional potential
- Dissimilatory nitrate reduction, anaerobic fatty acid β-oxidation and amino acid degradation associated with CAC score
Original publication
Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort. Circulation. Published 12 July 2023. doi:10.1161/circulationaha.123.063914
Summarised from the published abstract; every number is checked against it