Stress Perfusion Cardiac Magnetic Resonance vs Single-photon Emission Computed Tomography (SPECT) Imaging for Detection of Coronary Artery Disease
Authors' conclusion
Vasodilator stress perfusion CMR, as performed with gadobutrol 0.1 mmol/kg body weight, had superior diagnostic accuracy for diagnosis and exclusion of significant CAD vs gated SPECT.
Study context
- Population
- Adults with known or suspected coronary artery disease (CAD); reference standard 70% stenosis by quantitative coronary angiography (QCA) (negative coronary CT angiography could exclude CAD)
- Participants
- 294 adults
- Comparison
- Stress perfusion cardiovascular magnetic resonance (CMR) vs gated SPECT
- Primary endpoint
- Noninferiority of stress perfusion CMR vs SPECT for detecting and excluding significant CAD (prespecified secondary objective)
Methodological detailsdiagnostic accuracy, international, multicenter, prospective, Phase 3, prespecified secondary objective, blinded central core lab readers, per-patient analysis
- Diagnostic accuracy
- International
- Multicenter
- Prospective
- Phase 3
- Prespecified secondary objective
- Blinded central core lab readers
- Per-patient analysis
Primary result
As reported in the abstract
Diagnostic performance, CMR vs gated SPECT
- Sensitivity of CMR for 70% QCA stenosis noninferior and nonsuperior to gated SPECT
- CMR vs SPECT: P = 0.002
- CMR vs SPECT: P < 0.001
- CMR vs SPECT: P = 0.003
- CMR vs SPECT: P < 0.001
- CMR vs SPECT: P = 0.041
Secondary outcomes
Prevalence of significant CAD
- Prevalence of significant CAD
- 24.5% (n = 72 of 294)
Original publication
Stress Perfusion Cardiac Magnetic Resonance vs SPECT Imaging for Detection of Coronary Artery Disease. J Am Coll Cardiol. Published 7 November 2023. doi:10.
Summarised from the published abstract; every number is checked against it