Coronary disease & ACSSecondary analysis
Stress Perfusion Cardiac Magnetic Resonance vs Single-photon Emission Computed Tomography (SPECT) Imaging for Detection of Coronary Artery Disease
- Secondary analysis of the GadaCAD2 trial (diagnostic accuracy)
- international
- multicenter
- prospective
- Phase 3
- prespecified secondary objective
- blinded central core lab readers
- per-patient analysis
Authors' conclusion
Vasodilator stress perfusion CMR, as performed with gadobutrol 0.1 mmol/kg body weight, had superior diagnostic accuracy for diagnosis and exclusion of significant CAD vs gated SPECT.
Study context
- Population
- Adults with known or suspected coronary artery disease (CAD); reference standard 70% stenosis by quantitative coronary angiography (QCA) (negative coronary CT angiography could exclude CAD)
- Participants
- 294 adults
- Comparison
- Stress perfusion cardiovascular magnetic resonance (CMR) vs gated SPECT
- Primary endpoint
- Noninferiority of stress perfusion CMR vs SPECT for detecting and excluding significant CAD (prespecified secondary objective)
Primary result
As reported in the abstract
Diagnostic performance, CMR vs gated SPECT
- Sensitivity of CMR for 70% QCA stenosis noninferior and nonsuperior to gated SPECT
- CMR vs SPECT: P = 0.002
- CMR vs SPECT: P < 0.001
- CMR vs SPECT: P = 0.003
- CMR vs SPECT: P < 0.001
- CMR vs SPECT: P = 0.041
Secondary outcomes
Prevalence of significant CAD
- Prevalence of significant CAD
- 24.5% (n = 72 of 294)
Original publication
Stress Perfusion Cardiac Magnetic Resonance vs SPECT Imaging for Detection of Coronary Artery Disease. J Am Coll Cardiol. Published 7 November 2023. doi:10.1016/j.jacc.2023.08.046
Summarised from the published abstract; every number is checked against it