Coronary disease & ACSDiagnostic or prognostic study
Stress Perfusion Cardiac Magnetic Resonance (CMR) to Prognosticate for Left Main and High Risk Multivessel Coronary Artery Disease and Major Cardiovascular Adverse Events
- Prognostic cohort study
- multicentre
- 13-center
Authors' conclusion
The absence of ischemia on vasodilator stress perfusion CMR was associated with a very low likelihood of angiographically verified high-risk coronary artery disease and its associated events.
Study context
- Population
- Consecutive patients from the expanded cohort of the 13-center SPINS study undergoing vasodilator stress perfusion CMR
- Participants
- 4,144 patients
- Comparison
- Ischaemia vs no ischaemia on stress perfusion CMR
- Ischemian = 760
- Outcome
- Primary composite outcome:
- New diagnosis of LM/MVD
- Acute MI
- CV death
- Follow-up
- 4-year follow-up
Performance
Primary composite outcome
Adjusted hazard ratio
4.55
95% CI 3.32–6.25
P < 0.001
By group
Ischemia vs No ischemia
adjusted HR 4.55 (95% CI 3.32–6.25); P < 0.001
As reported in the abstract
- Patients with primary composite outcome (overall)
- 336 (8.1%)
- New diagnoses of left main (LM)/MVD
- 182 (4.4%)
- Acute myocardial infarction (MI)
- 96 (2.3%)
- CV deaths
- 58 (1.4%)
Further findings
| Outcome | adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Acute MI and CV death | 4.31 (3.08–6.05) | P < 0.001 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Annual event rate
| Outcome | Ischemia | No ischemia | Estimate | P value |
|---|---|---|---|---|
| LM disease | 0.9% | 0.08% | ||
| High-risk MVD | 5.6% | 0.3% |
Original publication
Stress Perfusion CMR to Prognosticate for Left Main and High Risk Multivessel Coronary Artery Disease and Major Cardiovascular Adverse Events. JACC Cardiovasc Imaging. Published 17 August 2026. doi:10.1016/j.jcmg.2026.06.010
Summarised from the published abstract; every number is checked against it