Arrhythmias & electrophysiology
Stroke Risk-Based Anticoagulation After Atrial Fibrillation Ablation: ALONE-AF Post-Hoc Analysis
- post-hoc analysis of the Long-Term Anticoagulation Discontinuation after Catheter Ablation for Atrial Fibrillation (ALONE-AF) trial
- exploratory
- stratified by CHA2DS2-VASc score ≤2 and ≥3
- Kaplan-Meier method
- competing risk analysis accounting for atrial fibrillation (AF) recurrence
+4 more
- exploratory
- stratified by CHA2DS2-VASc score ≤2 and ≥3
- Kaplan-Meier method
- competing risk analysis accounting for atrial fibrillation (AF) recurrence
Authors' conclusion
In this exploratory post-hoc analysis, no statistically significant differences in outcomes were observed between OAC strategies when stratified by CHA2DS2-VASc score, though event numbers were limited. Larger prospective trials are needed to confirm these observations.
Study context
- Population
- 840 ALONE-AF trial patients after catheter ablation for atrial fibrillation, stratified by CHA2DS2-VASc score (≤2 or ≥3)CHA2DS2-VASc score ≤2 (mean age 62.0±7.5 years, 15.9% female) 584 · CHA2DS2-VASc score ≥3 (mean age 68.9±7.3 years, 45.3% female) 256
- Participants
- 840 patients
- Comparison
- Within each stratum, outcomes were compared between the oral anticoagulant (OAC) discontinuation and continuation subgroups.
- Primary endpoint
- Primary outcome:
- Stroke
- Systemic embolism
- Major bleeding
- Follow-up
- 2 years
Primary result
As reported in the abstract
Primary outcome:
- Stroke
- Systemic embolism
- Major bleeding
- CHA2DS2-VASc ≤2 stratum
- absolute difference −1.9 percentage points percentage points; P = 0.066
- CHA2DS2-VASc ≥3 stratum; events occurred in the continuation subgroup only
- absolute difference −1.8 percentage points percentage points; P = 0.172
Safety
Major bleeding
- All major bleeding events occurred in the continuation subgroups
- n=5
Original publication
Stroke Risk-Based Anticoagulation After Atrial Fibrillation Ablation: ALONE-AF Post-Hoc Analysis. Heart Rhythm. Published 16 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it