Arrhythmias & electrophysiology
Structural, Functional, and Electrical Remodeling of the Atria With Reduced Cardiorespiratory Fitness: Implications for Atrial Fibrillation (AF)
Authors' conclusion
Reduced CRF in patients with AF is independently associated with worse LA disease involving functional and electrical changes.
Study context
- Population
- Patients with symptomatic AF undergoing catheter ablation
- Participants
- 100 patients
- Exposure
- Reduced cardiorespiratory fitness (CRF) vs preserved CRF
- Reduced CRFn = 43
- Preserved CRFn = 57reference
- Outcome
- LA stiffness, LA emptying fraction, LA reservoir strain, LA voltage and conduction (reduced vs preserved CRF)
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
- Reduced CRF vs Preserved CRF: P = 0.004
- Reduced CRF vs Preserved CRF: P = 0.006
- Reduced CRF vs Preserved CRF: P < 0.001
- Reduced CRF vs Preserved CRF: P = 0.039
- Reduced CRF vs Preserved CRF: P = 0.027
- Reduced CRF vs Preserved CRF: P = 0.04
- Reduced CRF vs Preserved CRF: P = 0.02
Observational data: associations, not effects.
Further findings
Multivariable analysis: peak oxygen consumption
- Independently associated with left atrial (LA) stiffness
- P = 0.003
- Independently associated with LA conduction velocities
- P = 0.04
Original publication
Structural, Functional, and Electrical Remodeling of the Atria With Reduced Cardiorespiratory Fitness: Implications for AF. JACC Clin Electrophysiol. Published 16 May 2024. doi:10.
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