Coronary disease & ACSTrial design
Study design for an emulated trial of a 2 arm, parallel, stratified, adaptive, randomized controlled trial (RCT) of coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) in people requiring myocardial revascularization at high risk (High-Risk REVASC)
- Study design for an emulated trial
- routinely collected health data
- trial emulation methodology
- latent class analysis
- instrumental variable analysis
Study context
- Population
- Patients who require multivessel myocardial revascularization with at least one high-risk characteristic: age >75 years, female, diagnosed with acute coronary syndrome, heart failure, chronic kidney disease, peripheral vascular disease, or intermediate frailty risk
- Planned comparison
- CABG versus PCI in high-risk patients
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Study design for an emulated trial of a 2 arm, parallel, stratified, adaptive, RCT of CABG versus PCI in people requiring myocardial revascularization at high risk (High-Risk REVASC). Am Heart J. Published 2 February 2026. doi:10.1016/j.ahj.2026.107368
Summarised from the published abstract; every number is checked against it