Prevention & lipidsCross-sectional study
Subclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: a multi-omics study
- Cross-sectional study
- multi-omics
- mediation analysis
Authors' conclusion
The presence, extension, and progression of subclinical atherosclerosis in middle-aged asymptomatic individuals are associated with an acceleration in the Grim epigenetic age.
Study context
- Population
- Middle-aged asymptomatic individuals from the Progression of Early Subclinical Atherosclerosis study
- Participants
- 391 individuals
- Exposure
- Subclinical atherosclerosis vs epigenetic age acceleration
- Outcome
- Association of subclinical atherosclerosis with accelerated epigenetic age
Main finding
As reported in the abstract
- Presence, extension and progression of subclinical atherosclerosis associated with significant Grim epigenetic age acceleration, regardless of traditional CV risk factors
- Accelerated Grim epigenetic age characterised by increased systemic inflammation and associated with a low-grade chronic inflammation score
- Mediation analysis: pro-inflammatory pathways (IL6, Inflammasome, IL10) and genes (IL1B, OSM, TLR5, CD14) mediate the association
Observational data: associations, not effects.
Original publication
Subclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: a multi-omics study. Eur Heart J. Published 20 June 2023. doi:10.1093/eurheartj/ehad361
Summarised from the published abstract; every number is checked against it