Subclinical atherosclerosis in women after pre-eclampsia: a systematic review and meta-analysis
Pooled result · CIMT (26 studies)Result — go to the resultStandardised mean difference 0.63 95% CI 0.32–0.93Authors' conclusion
Among women with a history of pre-eclampsia, subclinical atherosclerosis can be seen during pregnancy and persists long term. Our review supports the importance of early follow-up in patients who have had pre-eclampsia.
Study context
- Population
- Women with a history of pre-eclampsiawomen in 35 case-control studies, 3376 had a history of pre-eclampsia
- Participants
- 20,235 women
- Comparison
- Associations between pre-eclampsia and subclinical atherosclerosis
- Pre-eclampsian = 3,376
- Outcome
- CIMT (26 studies)
Methodological detailsCommon and random effects models
- Common and random effects models
Pooled result
As reported in the abstract
Standardised mean difference
0.63
95% CI 0.32–0.93
Pre-eclampsiavs No pre-eclampsia
standardised mean difference 0.63 (95% CI 0.32–0.93)
Further pooled results
| Outcome | Standardised mean difference (95% CI) | |
|---|---|---|
| CIMT · during pregnancyIncreased CIMT with pre-eclampsia | 0.65 (0.33–0.98) | |
| CIMT · 12 months post partumIncreased CIMT with pre-eclampsia | 0.84 (0.20–1.47) | |
| CIMT · beyond 12 months post partumIncreased CIMT with pre-eclampsia | 0.50 (0.01–0.99) | |
| −1012Difference (linear scale) |
| Outcome | Odds (95% CI) |
|---|---|
| Subclinical atherosclerosis by CAC (8 studies)Times higher with pre-eclampsia | 1.57 (1.39–1.77) |
Original publication
Subclinical atherosclerosis in women after pre-eclampsia: a systematic review and meta-analysis. Heart. Published 11 August 2025. doi:10.
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