Coronary disease & ACSCross-sectional study
Subclinical Coronary Atherosclerosis and Retinal Optical Coherence Tomography Angiography
- Cross-sectional study
- single-centre
Authors' conclusion
In this cross-sectional cohort study, reduced retinal PFVD was independently associated with subclinical coronary atherosclerosis in a population with elevated vascular risk.
Study context
- Population
- Asymptomatic individuals with elevated CV risk self-referred for health screening with coronary CT angiography and retinal optical coherence tomography angiography (OCTA), Asan Medical Center, Seoul, 2015–20201,286 eyes analysed
- Participants
- 1,286 individuals
- Exposure
- Lowest vs highest quartile of retinal parafoveal vascular density (PFVD)
- Outcome
- Association between OCTA parameters and coronary CT angiography parameters
Main finding
As reported in the abstract
Obstructive and severe CAD, lowest vs highest quartile of SCP PFVD
Lowest quartile SCP PFVD vs Highest quartile SCP PFVDAdjusted odds ratio (95% CI)
obstructive CAD
2.91(1.83–4.73)
severe CAD
3.30(1.55–7.91)
Observational data: associations, not effects.
Further findings
Deep capillary plexus (DCP) PFVD
- Similar but attenuated associations for DCP PFVD
PFVD as continuous variable
- Linear inverse association between PFVD and coronary artery disease (CAD) burden
Discrimination of models with CV risk factors plus PFVD
- AUC for severe CAD
- 0.79 (95% CI, 0.75-0.82)
- AUC for obstructive CAD
- 0.78 (95% CI, 0.76-0.81)
- AUC for segment stenosis score (SSS) ≥10
- 0.77 (95% CI, 0.74-0.80)
- Superficial capillary plexus (SCP) superior to DCP
Original publication
Subclinical Coronary Atherosclerosis and Retinal Optical Coherence Tomography Angiography. JAMA Cardiol. Published 1 November 2025. doi:10.1001/jamacardio.2025.3036
Summarised from the published abstract; every number is checked against it