HypertensionCohort study
Subclinical Primary Aldosteronism and Cardiovascular Health: A Population-Based Cohort Study
- Prospective cohort study
- population-based
Authors' conclusion
Independent of brachial BP, a biochemical phenotype of subclinical primary aldosteronism is negatively associated with cardiovascular health, including greater arterial stiffness, adverse cardiac remodeling, and incident hypertension.
Study context
- Population
- Adults aged 40–69 years from the randomly sampled population-based CARTaGENE cohort (Québec, Canada)
- Participants
- 1,284 adults
- Exposure
- Higher vs lower aldosterone-to-renin ratio
- Outcome
- Arterial stiffness (central BP, pulse wave velocity), adverse cardiac remodeling on CMR (indexed maximum left atrial volume, LV mass index, LV remodeling index, LV hypertrophy) and incident hypertension
Main finding
As reported in the abstract
Higher aldosterone-to-renin ratio associated with increased central blood pressure (BP), pulse wave velocity, indexed maximum left atrial volume, LV mass index and LV remodeling index
all P<0.05
Higher aldosterone-to-renin ratio: odds of LV hypertrophy, OR
1.32 (1.002-1.73) (95% CI)
Higher aldosterone-to-renin ratio: odds of incident hypertension, OR
1.29 (1.03-1.62) (95% CI)
Observational data: associations, not effects.
Further findings
Participants with normal BP (subgroup)
- All associations consistent in participants with normal BP
Original publication
Summarised from the published abstract; every number is checked against it