Heart failure & cardiomyopathiesRandomised controlled trial
Supervised Exercise Training in Patients with Advanced Heart Failure and Left Ventricular Assist Device: A Multicentre Randomized Controlled Trial (Ex-VAD Trial)
- Randomised controlled trial
- multicentre
- prospective
- 2:1 randomisation
Authors' conclusion
In patients with advanced heart failure and LVAD, 12 weeks of exercise training did not improve peakVO2 but demonstrated positive effects on submaximal exercise capacity and physical quality of life.
Study context
- Population
- Patients with stable advanced HF and left ventricular assist device (LVAD)54 analysed
- Participants
- 64 patients
- Comparison
- Supervised exercise training vs usual care
- Primary endpoint
- Change in peakVO2
- Follow-up
- 12 weeks
Primary result
As reported in the abstract
Mean difference in change of peakVO2
0.826 ml/min/kg (95% CI −0.37, 2.03; p = 0.183)
Secondary outcomes
| Outcome | mean increase (m) (95% CI) | P value | |
|---|---|---|---|
| 6-min walk distance · 12 weeks | 43.4 (16.9–69.9) | P = 0.0024 | |
| −50050100Difference, m (linear scale) |
| Outcome | mean (95% CI) | P value |
|---|---|---|
| KCCQ physical domain score · 12 weeks | 14.3 (3.7–24.9) | P = 0.0124 |
Adherence
- Overall adherence
- 71%
Safety
Adverse events
- No differences in adverse events between groups
Original publication
Supervised Exercise Training in Patients with Advanced Heart Failure and Left Ventricular Assist Device: A Multicentre Randomized Controlled Trial (Ex-VAD Trial). Eur J Heart Fail. Published 26 September 2023. doi:10.1002/ejhf.3032
Summarised from the published abstract; every number is checked against it