Arrhythmias & electrophysiologyResearch article
Supine Hypertension as a Predictor of Atrial Fibrillation
- Analysis of UK Biobank participants
Authors' conclusion
Supine hypertension is independently associated with increased AF risk, especially in younger adults. Seated hypertension was not independently associated with AF risk after adjustment. These findings suggest that supine BP may capture prognostic information beyond seated BP measurements.
Study context
- Population
- UK Biobank participants without prior cardiovascular disease or antihypertensive treatment (mean age 63.1 ± 7.7 years; 44.0% male)UK Biobank participants analyzed
- Participants
- 24,901 participants
- Comparison
- 4 groups based on the presence of seated and/or supine hypertension
- Outcome
- Incident AF
- Follow-up
- Median 4.5 years
Main finding
As reported in the abstract
Estimate (95% CI)
supine systolic BPindependently associated; the abstract names no comparator
aHR 1.12 per 10 mm Hg increase(1.05–1.20)
supine-only hypertensionSupine hypertension; the abstract names no comparator
aHR 1.38(1.09–1.75)
both seated and supine hypertensionthe abstract names no comparator
aHR 1.35(1.01–1.81)
Per 10 mm Hg increase, as printed
Further findings
Atrial fibrillation (AF) risk prediction with supine hypertension (Harrell C-index)
- Harrell C-index (as printed: 0.553 vs 0.576)
- 0.553 vs 0.576
- P = 0.033
Net reclassification improvement
- net reclassification improvement
- 22.3%
- P < 0.001
Supine hypertension and AF by age (subgroup)
- In participants <65 years, supine hypertension showed the strongest association with AF
- No significant association in older adults
Original publication
Supine Hypertension as a Predictor of Atrial Fibrillation. JACC Adv. Published 9 July 2026. doi:10.1016/j.jacadv.2026.102960
Summarised from the published abstract; every number is checked against it