Surgical Enlargement of the Aortic Root Does Not Increase the Operative Risk of Aortic Valve Replacement
Main finding · In-hospital mortalityResult — go to the resultOdds ratio 1.03 95% CI 0.75–1.41Authors' conclusion
In the largest analysis to date, ARE was not associated with increased risk of mortality or adverse events.
Study context
- Population
- Patients undergoing aortic valve replacement (AVR) at a single institution, 1990–2014; aortic dissection and active endocarditis excluded
- Participants
- 7,039 patients
- Exposure
- AVR+aortic root enlargement (ARE) vs AVR alone
- AVR+AREn = 1,854
- AVRn = 5,185reference
- Outcome
- In-hospital mortality
Methodological detailssingle-centre, propensity-score matched, multivariable adjusted
- Single-centre
- Propensity-score matched
- Multivariable adjusted
Main finding
As reported in the abstract
Odds ratio
1.03
95% CI 0.75–1.41
P = 0.85
By group
AVR+ARE vs AVR
OR 1.03 (95% CI 0.75–1.41); P = 0.85
Observational data: associations, not effects.
Further findings
In-hospital mortality, isolated AVR (subgroup)
P = 0.29
Mean
| Outcome | AVR+ARE | AVR | P value |
|---|---|---|---|
| Prosthesis size implanted | 23.4 (SD 2.1) | 24.1 (SD 2.3) | P < 0.001 |
Safety
- AVR+ARE not associated with increased risk of postoperative adverse events
Original publication
Surgical Enlargement of the Aortic Root Does Not Increase the Operative Risk of Aortic Valve Replacement. Circulation. Published 22 November 2017. doi:10.
Summarised from the published abstract; every number is checked against it