Acute cardiac care & resuscitation
Survival After Intravenous Versus Intraosseous Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Shock-Refractory Cardiac Arrest
Authors' conclusion
We found no significant effect modification by drug administration route for amiodarone or lidocaine in comparison with placebo during out-of-hospital cardiac arrest. However, point estimates for the effects of both drugs in comparison with placebo were significantly greater for the intravenous than for the intraosseous route across virtually all outcomes and beneficial only for the intravenous route.
Study context
- Population
- Adults with shock-refractory VF/pulseless VT OHCA2,358 IV, 661 intraosseous
- Participants
- 3,019 adults
- Comparison
- Amiodarone or lidocaine vs placebo, stratified by IV vs intraosseous route
- Primary endpoint
- Survival to hospital discharge
Methodological detailsprespecified analysis, placebo-controlled
- Prespecified analysis
- Placebo-controlled
Primary result
As reported in the abstract
- Overall hospital discharge survival
- 23%
Further findings
Survival to hospital admission; neurological outcome at discharge
- Admission survival increased significantly with IV but not intraosseous drugs; favored improved neurological outcome
IV vs intraosseous placebo
- No outcome differences between IV and intraosseous placebo
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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