Coronary disease & ACSSecondary analysis
Symptoms as a Predictor of the Placebo-Controlled Efficacy of Percutaneous Coronary Intervention (PCI) in Stable Coronary Artery Disease
- Secondary analysis of the ORBITA-2 randomised trial
- placebo-controlled
- Bayesian ordinal regression
Authors' conclusion
Although symptom severity and nature were poorly associated with disease severity, the nature of symptoms powerfully predicted the placebo-controlled efficacy of PCI.
Study context
- Population
- Stable CAD with little or no antianginal medication
- Comparison
- Presenting symptoms vs disease severity and as predictors of placebo-controlled PCI efficacy
Primary result
As reported in the abstract
Symptoms vs disease severity and as predictors of PCI efficacy
- Angina symptom score vs QCA diameter stenosis, ordinal correlation coefficient
- 0.06 (95% CrI 0.00-0.08)
- Angina symptom score vs stress echocardiography score, ordinal correlation coefficient
- 0.09 (95% CrI 0.02-0.10)
- Angina symptom score vs fractional flow reserve, ordinal correlation coefficient
- 0.04 (95% CrI −0.03 to 0.07)
- Angina symptom score vs instantaneous wave-free ratio, ordinal correlation coefficient
- 0.04 (95% CrI −0.01 to 0.07)
- Rose angina as predictor of placebo-controlled PCI efficacy (angina symptom score), OR
- 1.9 (95% CrI 1.6-2.1; PrInteraction = 99.9%)
- Guideline-based typical angina as predictor of placebo-controlled PCI efficacy (angina symptom score), OR
- 1.8 (95% CrI 1.6-2.1; PrInteraction = 99.9%)
Further findings
Prerandomization characteristics
- Median daily angina episodes (Q1-Q3: 0.4-1.6)
- 0.8
- Rose angina
- 64%
- QCA diameter stenosis (Q1-Q3: 49%-74%)
- 61%
- Stress echocardiography score (Q1-Q3: 0.0-2.7)
- 1.0
- Fractional flow reserve (Q1-Q3: 0.49-0.75)
- 0.63
- Instantaneous wave-free ratio (Q1-Q3: 0.55-0.87)
- 0.78
Original publication
Symptoms as a Predictor of the Placebo-Controlled Efficacy of PCI in Stable Coronary Artery Disease. J Am Coll Cardiol. Published 15 May 2024. doi:10.1016/j.jacc.2024.04.016
Summarised from the published abstract; every number is checked against it