Acute cardiac care & resuscitationSecondary analysis
Symptoms of anxiety and depression after out-of-hospital cardiac arrest: an exploratory dyadic analysis of survivors and their cohabiting spouses or partners from the BOX trial
- observational exploratory substudy
- three-month follow-up data from the Blood Pressure and Oxygenation Targets after Cardiac Arrest (BOX)-trial
- restricted to cohabiting survivor-partner dyads
Authors' conclusion
Symptoms of anxiety and depression did not differ in survivors and their spouse/partners. Higher age was associated with lower scores of anxiety and depression among survivors, and poorer self-rated health with higher symptom-scores in both.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) survivors and their cohabiting spouses/partnerssurvivor-partner dyads included, among 321 eligible OHCA survivors
- Participants
- 200 participants
- Comparison
- compare symptoms of anxiety and depression between survivors and cohabiting spouses/partners
Primary result
As reported in the abstract
HADS-A · three-month follow-up
survivors
4
median · IQR 1–7
spouses/partners
5
median · IQR 1–8
P = 0.107
Further findings
Median
| Outcome | survivors | spouses/partners | β (95% CI) | P value |
|---|---|---|---|---|
| HADS-D · three-month follow-up · paired comparison | 1 (IQR 0–4) | 1 (IQR 0–3) | P = 0.290 | |
| Association of higher age with HADS-A and HADS-D among survivors — higher age · HADS-A; higher age associated with lower scores · adjusted regression analyses among survivors | −0.065 (−0.125 to −0.025) | P = 0.012 | ||
| Association of higher age with HADS-A and HADS-D among survivors — higher age · HADS-D; higher age associated with lower scores · adjusted regression analyses among survivors | −0.040 (−0.090 to −0.00) | P = 0.037 |
Self-rated health and HADS-A/HADS-D (sensitivity analyses)
- poorer self-rated health was associated with higher scores of HADS-A and HADS-D in both parts
- poorer survivor self-rated health was associated with higher scores of HADS-D among spouses/partners
- sensitivity analyses
Original publication
Symptoms of anxiety and depression after out-of-hospital cardiac arrest: an exploratory dyadic analysis of survivors and their cohabiting spouses or partners from the BOX trial. Resuscitation. Published 25 May 2026. doi:10.1016/j.resuscitation.2026.111150
Summarised from the published abstract; every number is checked against it